Pada musim 2005-06, untuk pertama kalinya dalam sejarah, Udinese mengikuti kejuaraan antar klub Eropa yang paling bergengsi, Liga Champions. Pada babak kualifikasi, Udinese menyingkirkan tim Portugal, Sporting Lisbon, Pada babak final, Udinese dua kali mengalahkan juara Yunani, Panathinaikos, namun gagal melaju ke babak selanjutnya karena pada pertandingan grup terakhir gagal menahan imbang juara Spanyol, Barcelona.
Mantan penyerang Udinese, Vincenzo Iaquinta, merupakan salah satu anggota skuat tim nasional Italia pada Piala Dunia 2006.
Pada awal musim 2007/2008, tim ini banyak ditinggalkan para pemain pilarnya, seperti Morgan De Sanctis, Vincenzo Iaquinta, Sulley Ali Muntari, dan Cesare Natali.
| Goalkeeper | ||||||
|---|---|---|---|---|---|---|
| 31 | Orestis Karnezis |
| Greece | ||
| 97 | Alex Meret |
| Italy | ||
| 40 | Samuele Perisan |
| Italy | ||
| 90 | Rafael Romo |
| Venezuela | ||
| Defender | ||||||
|
| 53 | Ali Adnan |
| Iraq | ||
|
| 32 | Agostino Camigliano |
| Italy | ||
| 5 | Danilo |
| Brazil | ||
| 11 | Maurizio Domizzi |
| Italy | ||
| 30 | Felipe |
| Brazil | ||
| 75 | Thomas Heurtaux |
| France | ||
|
| 13 | Emanuel Insúa |
| Argentina | ||
| 26 | Giovanni Pasquale |
| Italy | ||
| 89 | Iván Piris |
| Paraguay | ||
| 2 | Molla Wague |
| Mali | ||
| 27 | Silvan Widmer |
| Switzerland | ||
| Midfielder | ||||||
| 7 | Emmanuel Agyemang-Badu |
| Ghana | ||
| 8 | Bruno Fernandes |
| Portugal | ||
| 21 | Edenilson |
| Brazil | ||
| 19 | Guilherme |
| Brazil | ||
| 16 | Manuel Iturra |
| Chile | ||
| 33 | Panagiotis Kone |
| Greece | ||
| 20 | Francesco Lodi |
| Italy | ||
|
| 95 | Lucas Evangelista |
| Brazil | ||
|
| 23 | Marquinho |
| Brazil | ||
| 52 | Alexander Merkel |
| Kazakhstan | ||
| Forward | ||||||
|
| 74 | Rodrigo Aguirre |
| Uruguay | ||
| 10 | Antonio Di Natale |
| Italy | ||
| 18 | Stipe Perica |
| Croatia | ||
| 77 | Cyril Théréau |
| France | ||
| 9 | Duván Zapata |
| Colombia | ||
| Manager | ||||||
| Stefano Colantuono |
| Italy | |||
| Ass. Manager | ||||||
|
| Roberto Beni |
| Italy | |||
| Goalkeeper-Coach | ||||||
|
| Mariano Coccia |
| Italy | |||
